Inactivation of human aldehyde dehydrogenase by isosorbide dinitrate.

Partially Irreversible Inactivation of Mitochondrial Aldehyde Dehydrogenase by Nitroglycerin*S⃞

Mitochondrial aldehyde dehydrogenase (ALDH2) may be involved in the biotransformation of glyceryl trinitrate (GTN), and the inactivation of ALDH2 by GTN may contribute to the phenomenon of nitrate tolerance. We studied the GTN-induced inactivation of ALDH2 by UV/visible absorption spectroscopy. Dehydrogenation of acetaldehyde and hydrolysis of p-nitrophenylacetate (p-NPA) were both inhibited by...

Human Liver Aldehyde Dehydrogenase

Human liver aldehyde dehydrogenase has been found to be capable of hydrolyzing p-nitrophenyl esters. Esterase and dehydrogenase activities exhibited identical ion exchange and affinity properties, indicating that the same protein catalyzes both reactions. Competitive inhibition of esterase activity by glyceraldehyde and chloral hydrate furnished evidence that p-nitrophenyl acetate was hydrolyze...

CHRONIC USE OF ISOSORBIDE DINITRATE/Danahy,

26. Bleifeld W, Mathey D, Hanrath P, Buss H, Effert S: Infarct size estimated from serial serum creatine phosphokinase in relation to left ventricular hemodynamics. Circulation 55: 303, 1977 27. Humphries JO, Pitt B, Griffith LSC, Ducci HH, Achuff S, Baird M, Schulze RA Jr: Coronary angiography and left ventriculography in survivors of transmural and subendocardial myocardial infarction. Circul...

Simultaneous measurement of plasma isosorbide dinitrate, isosorbide-2-mononitrate, and isosorbide-5-mononitrate by gas-liquid chromatography.

Vasodilator properties of nitroglycerin and isosorbide dinitrate during cardiopulmonary bypass.

In a placebo-controlled trial, we have studied the vasodilator properties of bolus doses of nitroglycerin (TNG) and isosorbide dinitrate (ISDN) in 32 patients during cardiopulmonary bypass with a constant pump flow. Blood volume of the venous reservoir and mean arterial pressure were recorded for 10 min after drug administration to detect changes in venous capacitance and arteriolar resistance,...